The case has been made for accidents and violent crimes being the products of an energy deficit (1), that is a decline in Daniel Atkinson energy charge which is reflected in the tissue pH (2). It might be instructive to consider the problem very broadly in terms of the entropy paradox confounding the second law of thermodynamics. The second law states that systems always progress from states of lower to states of higher entropy or more specifically never progressing from states of higher to states of lower entropy, entropy being a measure of the degree of disorder in a system. Living organisms are said to progress from states of higher to states of lower entropy in violation of the second law thereby creating an entropy paradox. Fred Adams, popular science writer and Professor of Physics at the University of Michigan, claims that the second law is not violated by living organisms for the universe as a whole still progresses to a state of higher entropy. In his book, "The Road to Reality", Sir Roger Penrose states that the entropy paradox is merely the delay in the inevitable progression to a state of higher entropy with ageing and death, the delay being cause by the ability of organisms to generatetheir own energy from from the consumption of nutrients and oxygen. If one accepts Sir Roger's explanation of the entropy paradox does that not mean that the sun, earth and all the other planets must also be living organisms? James Lovelock has proposed just that in his Gaia hypothesis which has been well received certainly in the popular science press. As Sir Roger points out the sun is in thermodynamic equilibrium with the earth transmitting as much energy to earth in the form of high energy bosons or photons in sunlight and receiving an equal amount back in a larger number of lower energy bosons (infrared waves) during the day and night. The inference is that the sun, earth and the planets all generate their own energy, the sun doing so by nuclear fusion of hydrogen. Humanity may be viewed as a giant organism populating an even larger organism, Gaia. In which case is the energy all of humanity generates progressing to a state of higher or lower entropy? That would seem to depend upon whether one considers all of humanity to be a thriving infant or an ageing adult. James Lovelock's accounting of the state of Gaia in his most recent book, "The Revenge of Gaia", leaves little doubt that humanity is an ageing adult. In which case global injury and violence may be a direct consequence of it the brain being most sensitive to a decline in energy charge as clinical experience of the critically ill has established. Perhaps one should take Fred Adams's view of entropy and conclude that humanity is progressing to a higher entropy state as a whole but exhibiting different degrees of entropy paradox in different communities and segments within those communities. In which case human conduct and energy charge are intimately related and all of the factors that might compromise the energy charge of all of humanity. These include the rapid growth in the population, the failure to meet all nutient demands, the failure to provide the gaseous environment conducive to optimizing oxidative phosphorylation, and the environmental toxins inhibiting oxidative phosporylation. Leplace determinism allows causes of past events to be determined and future events to be predictive with reasonable degrees of statistical confidence provided the initial conditions can be defined. The methodology has been refined for determining events at the Big Bang. It might be constructive to construct models with the future of humanity in mind. I doubt that the model will include global warming, nuclear war or any of the other Armageddon scenarios depicted in the popular press and entertainment industry. 1. Every driver needs metabolic testing and the information needs to be stored in a "black box" Richard G Fiddian-Green (22 July 2004) eLetter re: R A Shults, D A Sleet, R W Elder, G W Ryan, and M Sehgal Association between state level drinking and driving countermeasures and self reported alcohol impaired driving Inj Prev 2002; 8: 106-110 2. Richard G Fiddian-Green Irreversible shock, gastric intramucosal pH and energy charge. http://adc.bmjjournals.com/cgi/eletters/78/2/155#1417, 12 Mar 2005 www.cmaj.ca/cgi/eletters/174/5/620